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The positive expression of Ki67 protein and amount of apoptotic cells had been increased. Conclusion Conclusively, this research implicated that genipin suppresses cell expansion and stimulated apoptosis, and is the very first exploration showing that genipin causes OSCC mobile autophagy via PI3K/AKT/mTOR pathway inhibition. © 2020 Wei et al.Background Ligands consisting of two aryl moieties connected via a short spacer had been been shown to be powerful inhibitors of monoamine