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In vivo, their particular prevalent web effect is the one of systemic glucocorticoid antagonism, nonetheless they additionally show direct downregulation of AR and minor GR agonism during the cellular level. We hypothesize that anti-SARS-CoV-2 activity depends to some extent on this AR downregulation through reduced TMPRSS2 expression and modulation of ACE2 task. Considering the fact that hypercortisolemia is currently recommende