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6%) patients. Multivariable analysis found baseline-negative predictors of long-term healing of severe inflammation were ileal (as opposed to colonic) location (OR 0.00, [0.00-0.56] P=0.002) and presence of creeping fat on MRE (OR 0.00 [0.00-0.57]; P=0.001). Persistence of segmental MaRIA score 10.6 at week 14 was a negative predictor of healing at week 46 (OR 0.3 [0.04--0.38]; P0.001). In patients with CD, the absence of creeping fat detected at baseline MRE and location of severe inflammatory lesions are clinically rele