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05) in the liver of FLS chickens. Further analysis identifies site-specific demethylation (P 0.05) of m A in the mRNA of lipogenic genes, including FASN, SREBP1 and SCD. Moreover, GR binding to the promoter of FTO gene is highly enriched (P 0.05), while GR binding to the promoter of YTHDF2 gene is diminished (P 0.05). These results implicate a possible role of GR-mediated transcriptional regulation of m A metabolic genes on m A-depenent post-transcriptional activation of lipogenic genes and shed new light in the molecular
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