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CAL EFFICACY STAGE 1. There is a requirement for a personalized strategy to make MRI more accessible to men with suspicion of clinically significant prostate cancer (CSPC). To evaluate an optimized (Op)-MRI compared with biparametric (Bp)-MRI and multiparametric (Mp)-MRI for the diagnosis of CSPC. Two-center, retrospective. A total of 346 patients from center 1 and 292 patients from center 2. 3.0T scanners, T -weighted imaging (T WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging. Four radiologists interpre