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Despite pHM customization having been proved efficient in boosting the oral mucosal absorption of drugs, some possible risks, such as for example oral mucosal discomfort and teeth erosion brought on by the pH modifiers, should not been neglected during the formulation design process. This analysis aims to offer a quick introduction to your pHM modification concept in buccal/sublingual quantity forms, the properties of saliva pertaining to pHM adjustment, along with ideal dru