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The Most Effective ADHD Medication For Adults Adults with ADHD are usually prescribed stimulants. They aid in adjusting levels of two chemical messengers within the brain that regulate attention. Strattera (atomoxetine) is the most effective medication for adhd available for adults. It is available in a capsule that can either be taken with food or without. Most people find it efficient. It lasts longer than stimulants that have a shorter duration of action, such as amphetamine or methylphenidate. 1. Strattera Strattera (atomoxeti