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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person suffers from both ADHD and anxiety or depression, addressing the first disorder can improve the second. Mental health professionals usually prescribe antidepressants or stimulants for depression along with an ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most frequently used antidepressants