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y copyright. All rights reserved.BACKGROUND Alcohol consumption during pregnancy may damage the developing central nervous system of the fetus and lead to brain structural and functional deficits in the children, known as Fetal Alcohol Spectrum Disorders. The underlying mechanisms have not been fully elucidated. Previously using a third trimester-equivalent mouse model, ethanol-induced behavioral deficits (including spatial learning and memory dysfunction) in the mice were detected on postnatal day (PD) 35. The hippocampal formation is