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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can cause a variety of issues for adults. These issues can affect work, relationships, and mental health. Many times, people who suffer from untreated ADHD have low self-esteem and a negative perception of the world. This can cause them to feel like they are failing in their work and at home. Inattention and lack of Focus Finding it difficult to stay focused at times is normal, especially after a long day at school or