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Bad response to therapy, excessive chemotherapy toxicities, while the need for preventing contact with ionizing radiation make the effective clinical handling of patients with AT challenging for oncologists. We describe the good outcome of the LBCL with IRF4 rearrangement at stage III in a 7-year-old feminine client diagnosed with AT. The patient was treated according to the B-HR supply regarding the INTER-B-NHL-COP 2010 protocol, including the management of rituximab, cyclophosphamide, meth