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In conclusion, our results support the prediction of theoretical disease models showing predator can be a natural enemy for pathogen control, and also extend that predatory interactions interacting with vector preferences play the singularly joint effects on the spread of vector-borne pathogens.Methotrexate (MTX), as a folate antagonist is used for breast cancer chemotherapy, but its application due to the adverse side effects was limited. In this study, MTX were encapsulated in magnetic alginate beads coated with glutaraldehyde to con