https://proteasesinhibitors.co....m/marketing-regardin
Right here, we investigated the system of MM0299, a tetracyclic dicarboximide with anti-glioblastoma activity. MM0299 inhibits lanosterol synthase (LSS) and diverts sterol flux away from cholesterol into a "shunt" path that culminates in 24(S),25-epoxycholesterol (EPC). EPC synthesis following MM0299 treatment is actually required and adequate to block the rise of mouse and person glioma stem-like cells by depleting cellular cholesterol levels. MM0299 displays superior selectivit
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