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Insulin and the insulin-like growth factor (IGF) family play a key role in breast cancer (BC). In this study, we evaluated on a genomic scale the potential prognostic value of insulin signaling in early BC. Candidate genes were selected from the published literature and gene expression profiling experiments. Three publicly available BC datasets, containing gene expression data on 502 cases, were used to test the prognostic ability of the score. The gene signature was developed on GSE1456, containing microarray data from 159 patients, spl