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Taken together, our results indicate that the peak rate of transcription is a persistent property of a gene, and that differences in gene expression are modulated by temporal intermittency of the transcription.Inflammatory bowel disease (IBD) is an autoimmune disease with increasing incidence rate, and divided into ulcerative colitis (UC) and Crohn's disease (CD). And more and more experimental evidence supports that immune disorder is important in the pathogenesis of IBD. Our previous experiments have confirmed that TsKaSPI and TsAdSPI recombinant proteins