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Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease whose underlying mechanisms have been primarily investigated in mice after intratracheal instillation of a single dose of bleomycin. However, the model has significant limitations including the transient fibrosis which spontaneously resolves and its failure to fully rec