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To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n=88) and ε4-negative (n=251) groups. They were followed-up for up to 6 years to identify the development of FOG. To investigate the influence of CSF β-amyloid 1-42 (Aβ ) on the association between APOE ε4 and FOG, the patients were additionally dichotomized into "high-level" and "low-level" groups using three different cu