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1) To measure frequency and yield of blood cultures obtained for observation status adult patients with skin and soft tissue infection (SSTI), 2) describe how often blood cultures were performed according to Infectious Diseases Society of America (IDSA) SSTI guideline indications, 3) identify proportion of patients meeting Center for Medicare Services (CMS) sepsis criteria. Retrospective cohort. Tertiary academic center. Consecutive adult observation status patients hospitalized with SSTI between July 2017 and July 2018. We measured th