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However, relapse is still the main element influencing success. We aimed to investigate the result of allogeneic hematopoietic stem cellular transplantation (allo-HSCT) on reducing recurrence and enhancing the survival of high-risk pediatric t(8;21) AML based on minimal recurring disease (MRD)-guided treatment, and to further explore the prognostic factors to guide risk stratification treatment and recognize who can benefit from allo-HSCT. Methods Overall, 129 newly diagnosed pediatric t(8;21) AML c