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Herein, we opted for three major metabolites of OPFRs (BCIPP, BDCIPP, and DPHP) to investigate their potential endocrine disrupting results by in vitro, in vivo, and in silico assays. Three metabolites were agonistic to rat estrogenic receptor alpha (ERα) and antagonists to human being mineralocorticoid receptor (MR). BCIPP exerted hormonal disrupting effect contrasting to your negative reaction of their parental compound. Moreover it presents the strongest bin