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In this research, knockdown of Nrf2 by small interfering RNA (siRNA) transfection inhibited the consequence of CyCl on NF-κB signaling and apoptosis, recommending that there's functional crosstalk between Nrf2 and NF-κB. Our conclusions indicate the significant role of Nrf2 in inducing apoptosis through the involvement of NF-κB signaling in colorectal cancer cells, suggesting that CyCl can be utilized as a possible therapeutic agent for CRC.We report the morphologies of tin-doped indium