https://www.selleckchem.com/CDK.html
06; CHQ, P 0.05). In contrast, in C2C12 cells, 1mM leucine increased mTORC1 and S6K1 phosphorylation (P 0.05), which was inhibited by 2mg/ml chloroquine. Chloroquine (2mg/ml) was sufficient to disrupt mTORC1 signaling, and MyPS. Chloroquine did not inhibit amino acid-induced activation of mTORC1 signaling and skeletal MPS in humans as it does in C2C12 muscle cells. Therefore, different in vivo experimental approaches are required for confirming the precise role of the lysosome and amino acid sensing in human skeletal muscle. Trial registra
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