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We reported another case with a novel homozygous variant of WDR45B and showed the heterogeneity of clinical features. We reported another case with a novel homozygous variant of WDR45B and showed the heterogeneity of clinical features. Cognitive frailty can increase the risk of adverse health outcomes in older adults. Estimates of the prevalence of cognitive frailty among older adults with diabetes varied widely in literature. This study aimed to conduct a systematic review and meta-analysis to assess the pooled prevalence of cognitive