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Our study found that running had a short-term adverse effect on COMP and did not affect cartilage volume or thickness. Running has advantages in promoting nutrition penetrating into the cartilage as well as squeezing out the metabolic substance, such as water. Our study found that running had a short-term adverse effect on COMP and did not affect cartilage volume or thickness.The Hofmeister series is a qualitative ordering of ions according to their ability to precipitate proteins in aqueous solution and is extremely important to conside