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ifferent amphipathic copolymers in appropriate is an efficient and easy technique to synthesize complex and multifunctional nanoparticles.Copper is well known for its multifunctional biological effects including antibacterial and angiogenic activities, while silicon-containing bioceramic has proved to possess superior biological properties to hydroxyapatite (HA). In this work, CuO was introduced to silicocarnotite (Ca5(PO4)2SiO4, CPS) to simultaneously enhance its mechanical and antibacterial properties, and its cytocompatibility was also