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Pharmaceutical pollution has emerged as a highly concerned issue due to its adverse effects. Elevated concentrations of pharmaceuticals in water should be regulated to satisfy the requirement for the provision of clean water. Metal-organic frameworks (MOFs) with high specific surface area, controllable porous structure, and facile modification can serve as promising adsorbents for the removal of pharmaceutical contaminants from water. In this review, a selected collection illustrating the reliable strategies and concepts to prepare the MOF