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The COVID-19 pandemic, which has had the most tragic consequences, can also be viewed as a 'global natural experiment' in human-nature interactions that can provide unprecedented mechanistic insights into the complex processes and dynamics of these interactions and into possible strategies to manage them to best effect. A free Plain Language Summary can be found within the Supporting Information of this article. The Coronavirus Disease 2019 (COVID-19) pandemic has presented social distancing challenges leading healthcare systems to a