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0 [0.71-1.4]). Also, locoregional failure was similar between the two groups (aHR 1.1 [CI 0.68 - 1.7]). Tumors were PD-L1+ in 76% of cases, significantly more among HPV p16+ tumors (82% vs. 70%, p = .01). Interestingly, higher prevalence of PD-L1+ expression was seen in HPV p16+ patients with less then 10 pack-years of tobacco-smoking (93%) compared to HPV p16+ smokers (76%) or HPV p16-negative patients (70%) (p = .003).Conclusion PD-L1 expression had no prognostic significance in OPSCC patients treated with primary radiotherapy alone. A s