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Using benefits of the superior gene delivery/PT effect and NIR-II-enhanced medication delivery, RHNS-PGEA understood an amazing therapeutic effect of trimodal gene/PT/chemotherapy of malignant breast cancer treatment in vitro and in vivo. The present work offers a promising method for the rational design of polymer-inorganic nanohybrids with superior morphology when it comes to multimodal cancer therapy.Natural organic matter (NOM), organic micropollutants (OMPs), and harmful mi