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These forces disrupt lung barrier integrity, trigger proinflammatory mediator launch, and differentially regulate genetics and non-coding oligonucleotides including microRNAs. In this research, we identify miR-146a as a mechanosensitive microRNA in alveolar macrophages that features healing prospective to mitigate lung damage during technical ventilation. We use humanized in-vitro systems, mouse models, and biospecimens from clients to elucidate
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