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BACKGROUND Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by a traditional center-based and home-based programs. OBJECTIVE This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frailty older women. METHODS Thirty-one frail older women were allocated in two different groups home-based group (n=17, 71.5 ± 6.5 years) or center-based group (n=14, 68.4 ± 6.4 years). The exercise program