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Overall, at the outset of an outbreak like this, it is highly important to readily provide information to begin the evaluation necessary to understand the risks and begin containment activities. © 2020 Wiley Periodicals, Inc.Mammalian sirtuins (SIRTs 1-7), are a family of NAD+-dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs -3, -4, and -5 are located in the mitochondria and have been implicated in caloric restriction, oxidative st