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05). Microscopic assessment of the slides showed a significantly less enamel maturation in the experimental groups compared with the control group (P0.05). Morphine use by mothers decreased the fluorine content of tooth structure and retarded the maturity of the enamel of infants. Morphine use by mothers decreased the fluorine content of tooth structure and retarded the maturity of the enamel of infants.This research provides an overview of the historical advances of the maze tests that are widely used to asses