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The symbiotic relationship between insects and gut microbes contributes to their fitness by serving immense range of functions viz. nutrition and digestion, detoxification, communication and reproduction etc. However, this relationship between insect and gut microbes varies from mutualistic to pathogenic. Gut microbes become pathogenic when the healthy normal microbial composition is perturbed leading to the death of insect host. Spodoptera litura (Fab.) is a polyphagous pest that causes significant damage to many agricultural crops. Th