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05). A significant difference in favor of group "-" could also be detected after 3 weeks in terms of both acid phosphatases (p 0.05). In histology, no significant differences could be detected. Bone regeneration with bovine bone substitute material and collagen membrane shows a significantly earlier bone remodeling activity but does not seem to influence formation of new bone in histological samples. Bone regeneration with bovine bone substitute material and collagen membrane shows a significantly earlier bone remodeling activity but do