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The purpose of this study was to prevent anaemia caused on long-term phenytoin treatment among Epileptic patients. Therefore, two groups were categorised based on the duration of phenytoin namely, cases and control. The duration of Phenytoin treatment for case was 2 years while control had 2 years) compare to control with the Folate concentration of (7.01 ± 4.4 which was statistically significant (p less then 0.00. The experimental results have proved that a long-term phenytoin treatment significantly affects the concentratio