https://tmp195inhibitor.com/pd....-l1-phrase-inside-si
Upon agonist activation, GPCRs couple to G proteins and induce the activation of G protein-dependent signaling pathways. The agonist-activated GPCRs are also phosphorylated by G protein-coupled receptor kinases (GRKs), which promote their particular conversation with arrestins. Arrestin binding induces desensitization (i.e., incapacity to few to G proteins) and/or internalization of GPCRs. Arrestins not only desensitize and/or internalize GPCRs but in addition mediate other dow
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