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This work moves prominent G9a ligands forward as pharmacological tools to prove for a potentially combined, symptomatic and causal, therapy in PWS by bridging the gap between drug development for G-protein coupled receptors and G9a as an epigenetic effector in a multi-targeting approach.An amendment to this paper has been published and can be accessed via a link at the top of the paper.Image texture, the relative spatial arrangement of intensity values in an image, encodes valuable information about the scene. As it stands, much of th