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Currently, there is a problem of ineffective chemotherapy to trypanosomiasis and the increasing emergence of malarial drug-resistant parasites. This research aimed to develop new dipeptide-sulfonamides as antiprotozoal agents. Protozoan parasites cause severe diseases, with human African trypanosomaisis (HAT) and malaria leading the list. The noted deficiencies of existing antitrypanosomal drugs and the worldwide resurgence of malaria, accompanied by the springing up of widespread drug-resistant protozoan parasites, represent a huge cha