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In laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analysis, it really is difficult to quantitatively analyse a reduced level of titanium focus. Two techniques had been employed using a quadrupole mass spectrometer built with a collision/reaction cellular (CRC). In the 1st approach, the MS/MS mass-shift mode with oxygen reaction gas offered reliable and constant measurement of titanium as 48Ti16O+. In the 2nd strategy, the titanium focus had been dete