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The proposed models will promote early and accurate evaluation of the cardiac safety of new drugs. Lateral maxillary sinus augmentation (MSA) is a predictable bone regeneration technique in case of atrophy of the posterior-upper maxilla. Aimed at obtaining quantity and quality of bone suitable for receiving osseointegrated implants, its success is largely due to the skill of the surgeon, but also to the characteristics of the biomaterial used. Twenty-four patients needing MSA were included in the study. The patients were randomly allocated