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-electrode recordings in nerves.Excess circulating human growth hormone (hGH) in vivo is linked to metabolic and growth disorders such as cancer, diabetes and acromegaly. Consequently, there is considerable interest in developing antagonists of hGH action. Here, we present the design, synthesis and characterization of a 16-residue peptide (S1H) that inhibits hGH-mediated STAT5 phosphorylation (pSTAT5) in cultured cells. S1H was designed as a direct sequence mimetic of the site 1 mini-helix (residues 36-51) of wild-type hGH and acts by in
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