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One patient died after 81 days of ECMO run. Four patients were discharged and recovered to their prehospital quality of life without major disability. We achieved a high survival rate using ECMO in our low volume ECMO institution during the COVID-19 pandemic. Multidisciplinary decision-making and a team approach for the unclear pathology with an emerging infectious disease was effective and contributed to the survival rate.Three new matrine-type alkaloids, 8β-hydroxyoxysophoridine (1), 9β-hydroxysophoridine (2), 9β-hydroxyisosophocarpin