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LncRNA HOXA-AS2 was aberrantly upregulated and it may be involved in the regulation of cancer stem cells during oncogenic transformation. Consistently, lncRNA HOXA-AS2 expression was significantly upregulated in HCC and its higher expression positively correlated with poor prognosis and stem cell-related functions. Moreover, a specific cancer stem cell subpopulation with EPCAM , C-MYC and CK19 may exist in higher HOXA-AS2 expression HCC patients. LncRNA HOXA-AS2 plays pivotal roles in the occurrence and progression of HCC, which may act a
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