https://www.selleckchem.com/pr....oducts/indisulam.htm
Genetic variants in voltage-gated sodium channels (Na ) encoded by genes, responsible for I , and K 4.3 channels encoded by , responsible for the transient outward current (I ), contribute to the manifestation of both Brugada syndrome (BrS) and spinocerebellar ataxia (SCA19/22). We examined the hypothesis that K 4.3 and Na variants regulate each other's function, thus modulating I /I balance in cardiomyocytes and I /I balance in neurons. Bicistronic and other constructs were used to express WT or variant Na 1.5 and K 4.3 channels in H
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