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There were no abnormal changes in mouse body weight. The biodistribution results showed that Cur-IONPs accumulated mainly in the liver, spleen, and brain, while almost no Cur-IONPs were found in the kidney. The iron content in the liver remained high even 10days after the final injection, while the iron content in the spleen and brain had returned to normal levels by this time point, indicating their complete clearance. These results are significant and promising for the further application of Cur-IONPs as theragnostic nanoparticles. Th