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95, 8.07 and 4.34 mg L-1 at 24, 48 and 72 h, respectively. QSAR study revealed that MLR for S. rolfsii (r2 = 0.9834, q2= 0.8975) and A. solani (r2 = 0.9807, q2= 0.8713) and PLS for M. incognita (r2 = 0.9023, q2= 0.7818) were the best models.Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, arising either due to genetic mutations or from a variety of underlying diseases. This prospective observational study reports the clinical and laboratory data as well as the outcome of pediatric HLH in Egypt. HLH was diagnosed