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The introduced method significantly outperforms the compared approaches, in terms of the correlation with human judgments. CONCLUSIONS It is demonstrated that the presented NR-IQA method for the assessment of MR images is superior to the state-of-the-art NR techniques. The method would be beneficial for a wide range of image processing applications, assessing their outputs and affecting the directions of their development. © 2020 International Society for Magnetic Resonance in Medicine.The amino acid derivative reactivity assay (ADRA),