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129, P = 3.938 × 10-8; replication β = 0.102, P = 0.02. In A allele carriers, the relationship between childhood trauma and anxiety was moderated by general self-efficacy higher self-efficacy and childhood trauma resulted in low anxiety scores, and lower self-efficacy and childhood trauma in higher anxiety levels. In turn, TT homozygotes displayed increased anxiety as a function of childhood adversity unaffected by general self-efficacy. CONCLUSIONS Functional NPSR1 variation and childhood trauma are suggested as prime moderators in t