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Respiratory-sympathetic entrainment was quantified as percent of MSNA bursts during each respiratory epoch relative to the total burst count. Sympathetic BRS was similar between inspiration and expiration (-3.9±2.0 vs. -3.6±1.8 bursts/100heartbeats/mmHg; p=0.61) but greater during low vs. high lung volumes (-4.6±2.3 vs. -2.1±1.6 bursts/100heartbeats/mmHg; p0.05). These findings provide novel insight towards the mechanisms controlling within-breath modulation of sympathetic outflow in humans.Background Most studies that have evaluated the